Wingless signaling regulates winner/loser status in Minute cell competition
نویسندگان
چکیده
منابع مشابه
Phosphorylation of Mad controls competition between wingless and BMP signaling.
Bone morphogenetic proteins (BMPs) and Wnts are growth factors that provide essential patterning signals for cell proliferation and differentiation. Here, we describe a molecular mechanism by which the phosphorylation state of the Drosophila transcription factor Mad determines its ability to transduce either BMP or Wingless (Wg) signals. Previously, Mad was thought to function in gene transcrip...
متن کاملCell Signaling: Wingless and Glypicans Together Again
The role of the Glypican proteoglycans in Wingless signaling has been controversial. New studies show that the Glypican Dally-like can have both positive and negative effects on Wingless signaling; moreover, signaling can be regulated by removing Dally-like from the cell surface.
متن کاملPebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway.
Wingless (Wg)/Wnt signaling is essential for patterning invertebrate and vertebrate embryos, and inappropriate Wnt activity is associated with a variety of human cancers. Despite intensive study, Wnt pathway mechanisms are not fully understood. We have discovered a new mechanism for regulating the Wnt pathway: activity of a Rho guanine nucleotide exchange factor (GEF) encoded by pebble (pbl) in...
متن کاملFIRST SESSION: CELL COMPETITION IN DEVELOPMENT Genetic analysis of Minute cell competition
FUNDACIÓN RAMÓN ARECES FIRST SESSION: CELL COMPETITION IN DEVELOPMENT Genetic analysis of Minute cell competition Nicholas Baker Albert Einstein College. New York. USA. Ribosomal protein genes are usually haploinsufficient and their mutations lead to dominant growth defects. Heterozygous cells are out-competed by wild type cells. We isolated mutations that prevent the loss of Minute cells from ...
متن کاملWnt/Wingless signaling in Drosophila.
The Wingless (Wg) pathway represents one of the best-characterized intercellular signaling networks. Studies performed in Drosophila over the last 30 years have contributed to our understanding of the role of Wg signaling in the regulation of tissue growth, polarity, and patterning. These studies have revealed mechanisms conserved in the vertebrate Wnt pathways and illustrate the elegance of us...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes to Cells
سال: 2018
ISSN: 1356-9597
DOI: 10.1111/gtc.12568